Based on three research projects that have explored the soundscape of the city of Cali since 2008 (Cali Soundscape, Cali sound postcards and Sound and the ordering of a territory) this article presents the methodology developed in each project, the conclusions and the appropriateness of integrating both quantitative and qualitative approaches in a multidisciplinary framework. These findings serve as a methodological background and point of departure for a case study (in progress): Sound as cultural heritage in urban space: digital cartographies for the preservation of the sono-spatial memory of the graphic arts industry in the San Nicolás neighborhood (Santiago de Cali, 1894 – 2013). The project is funded by Colciencias and groups a team of architects, anthropologists, sociologists and historians that aim at approaching the phenomenon of urban sound in an interdisciplinary manner.